Article
Genetic basis of sex-specific resistance to neuro-oncogenesis in (BDIX x BDIV) F(2) rats.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2000
Winzen Bettina, Koelsch Bernd, Fischer Christine, Kindler-Röhrborn Andrea
Abstract excerpt
The identification of cancer susceptibility- and resistance-mediating genes is an essential prerequisite for prevention and early diagnosis of malignant tumors. Model organisms are helpful to identify variant alleles involved in pathways affecting individual cancer risk. BDIX and BDIV rats of both sexes are highly susceptible and resistant, respectively, to the development of N-ethyl-N-nitrosourea (ENU)-induced...
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