Article
Mapping cross-clade HIV-1 vaccine epitopes using a bioinformatics approach.
Vaccine - 1 Oct 2003
De Groot Anne S, Jesdale Bill, Martin William, Saint Aubin Caitlin, Sbai Hakima, Bosma Andrew, Lieberman Judy, Skowron Gail, Mansourati Fadi, Mayer Kenneth H
Abstract excerpt
UNLABELLED: The genomic variability of HIV viruses circulating in different regions of the world has impeded the development of a globally relevant HIV vaccine. Broadly conserved HIV-1 cytotoxic T cell (CTL) epitopes were identified by screening protein sequences in the Los Alamos National Laboratory (LANL) HIV sequence database with a sequence parsing and matching algorithm (Conservatrix). Putative HIV-1 CTL...
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