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Article

Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Miyaji Michihiko, Kortum Robert L, Surana Rishi, Li Wenmei, Woolard Kevin D, Simpson R Mark, Samelson Lawrence E, Sommers Connie L

Abstract excerpt

Germline mutation of the linker for activation of T cells (LAT) gene at the phospholipase C-gamma1 (PLC-gamma1)-binding site leads to a fatal lymphoproliferative disease in mice. The hyperactivated T cells that develop in these mice have defective T-cell antigen receptor (TCR)-induced calcium flu...

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Source

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Identifiers

PMID: 19667175
DOI: 10.1073/pnas.0903894106
PMCID: PMC2732887

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19667175-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.PMID 19667175Read ↗

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Semantic proximity Read ↗

A LAT mutation that inhibits T cell development yet induces lymphoproliferation.Semantic proximity Read ↗

Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.Semantic proximity Read ↗

The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.Semantic proximity Read ↗

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.Semantic proximity Read ↗

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read ↗

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.Semantic proximity Read ↗

Expression of a constitutively active p38α mutant in mice causes early death, anemia, and accumulation of immunosuppressive cells.Semantic proximity Read ↗

miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.Semantic proximity Read ↗

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.Semantic proximity Read ↗

Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency.Semantic proximity Read ↗

Th2 lymphoproliferative disorders resulting from defective LAT signalosomes.Semantic proximity Read ↗

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