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Article

Spontaneous Differentiation of T Follicular Helper Cells in LATY136F Mutant Mice.

Frontiers in immunology - 1 Jan 2021

O'Brien Sarah A, Zhu Minghua, Zhang Weiguo

Abstract excerpt

Mice with a mutation at the LAT-PLCγ1 binding site (Y136) have a defect in thymocyte development due to dampened TCR signaling. CD4+ T cells that do reach the periphery are hyper-activated and skewed to Th2. Over time, these mice develop an autoimmune-like syndrome, characterize by overproduction of Th2 cytokines, T cell infiltration into various organs, and B cell activation, isotype switching, and autoantibody...

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Source

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Identifiers

PMID: 33912184
DOI: 10.3389/fimmu.2021.656817
PMCID: PMC8072119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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