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Article

LatY136F knock-in mouse model for human IgG4-related disease.

PloS one - 1 Jan 2018

Yamada Kazunori, Zuka Masahiko, Ito Kiyoaki, Mizuguchi Keishi, Kakuchi Yasushi, Onoe Tamehito, Suzuki Yasunori, Yamagishi Masakazu, Izui Shozo, Malissen Marie, Malissen Bernard, Kawano Mitsuhiro

Abstract excerpt

BACKGROUND: The adaptor protein Linker for activation of T cell (LAT) is a key signaling hub used by the T cell antigen receptor. Mutant mice expressing loss-of-function mutations affecting LAT and including a mutation in which tyrosine 136 is replaced by a phenylalanine (LatY136F) develop lymphoproliferative disorder involving T helper type 2 effector cells capable of triggering a massive polyclonal B cell...

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Share to Adrenal Cortex Hormones
Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Pancreas

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Share to Salivary Glands

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Source

Open in PubMed Open full text

Identifiers

PMID: 29902238
DOI: 10.1371/journal.pone.0198417
PMCID: PMC6002065

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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