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Article

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.

Science (New York, N.Y.) - 14 Jun 2002

Aguado Enrique, Richelme Sylvie, Nuñez-Cruz Selene, Miazek Arkadiusz, Mura Anne-Marie, Richelme Mireille, Guo Xiao-Jun, Sainty Danielle, He Hai-Tao, Malissen Bernard, Malissen Marie

Abstract excerpt

The transmembrane protein LAT (linker for activation of T cells) couples the T cell receptor (TCR) to downstream signaling effectors. Mice homozygous for a mutation of a single LAT tyrosine residue showed impeded T cell development. However, later they accumulated polyclonal helper T (TH) cells that chronically produced type 2 cytokines in large amounts. This exaggerated TH2 differentiation caused tissue...

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Source

Identifiers

PMID: 12065839
DOI: 10.1126/science.1069057

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Induction of T helper type 2 immunity by a point mutation in the LAT adaptor.PMID 12065839Read ↗

A LAT mutation that inhibits T cell development yet induces lymphoproliferation.Semantic proximity Read ↗

LAT polices T cell activation.Semantic proximity Read ↗

Th2 lymphoproliferative disorders resulting from defective LAT signalosomes.Semantic proximity Read ↗

LAT regulates gammadelta T cell homeostasis and differentiation.Semantic proximity Read ↗

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Semantic proximity Read ↗

Human LAT mutation results in immune deficiency and autoimmunity but also raises questions about signaling pathways.Semantic proximity Read ↗

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read ↗

Activation of T lymphocytes and the role of the adapter LAT.Semantic proximity Read ↗

Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency.Semantic proximity Read ↗

LAT encodes T cell activation pathway balanceSemantic proximity Read ↗

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.Semantic proximity Read ↗

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Semantic proximity Read ↗

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