Article
Statistical evaluation and biological interpretation of non-random abundance in the E. coli K-12 genome of tetra- and pentanucleotide sequences related to VSP DNA mismatch repair.
Nucleic acids research - 11 Apr 1992
Merkl R, Kröger M, Rice P, Fritz H J
Abstract excerpt
The abundance of all tetra- and pentanucleotide sequences is calculated for a set of DNA sequence data comprising 767,393 nucleotides of the E. coli K-12 genome. Observed frequencies are compared to those expected from a Markov chain prediction algorithm. Systematic and extreme non-random representations are found for special sets of sequences. These are interpreted as arising from incorporation of a...
Topics
- Algorithms
- Bacillus subtilis
- Base Composition
- DNA Repair
- DNA Replication
- DNA, Bacterial
- DNA-Cytosine Methylases
- Escherichia coli
- Genome, Bacterial
- Markov Chains
- Mutation