Article
Evolutionary implications of the frequent horizontal transfer of mismatch repair genes.
Cell - 22 Nov 2000
Denamur E, Lecointre G, Darlu P, Tenaillon O, Acquaviva C, Sayada C, Sunjevaric I, Rothstein R, Elion J, Taddei F, Radman M, Matic I
Abstract excerpt
Mutation and subsequent recombination events create genetic diversity, which is subjected to natural selection. Bacterial mismatch repair (MMR) deficient mutants, exhibiting high mutation and homologous recombination rates, are frequently found in natural populations. Therefore, we have explored the possibility that MMR deficiency emerging in nature has left some "imprint" in the sequence of bacterial genomes....
Topics
- Adenosine Triphosphatases
- Alleles
- Bacterial Proteins
- Base Pair Mismatch
- DNA Repair
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins
- Evolution, Molecular
- Exodeoxyribonuclease V
- Exodeoxyribonucleases
- Genotype
- MutL Proteins