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Article

DNA structure constraint is probably a fundamental factor inducing CpG deficiency in bacteria.

Bioinformatics (Oxford, England) - 12 Dec 2004

Wang Yong, Leung Frederick C C

Abstract excerpt

MOTIVATION: It has been speculated that CpG dinucleotide deficiency in genomes is a consequence of DNA methylation. However, this hypothesis does not adequately explain CpG deficiency in bacteria. The hypothesis based on DNA structure constraint as an alternative explanation was therefore examined. RESULTS: By comparing real bacterial genomes and Markov artificial genomes in the second order, we found that the...

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PMID: 15247101
DOI: 10.1093/bioinformatics/bth393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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