Article
Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease.
Nature medicine - 1 Apr 2005
Lin Jingmei, Patel Sanjeevkumar R, Cheng Xu, Cho Eun Ah, Levitan Inna, Ullenbruch Matthew, Phan Sem H, Park John M, Dressler Gregory R
Abstract excerpt
The bone morphogenetic proteins (BMPs) profoundly affect embryonic development, differentiation and disease. BMP signaling is suppressed by cysteine-rich domain proteins, such as chordin, that sequester ligands from the BMP receptor. We describe a novel protein, KCP, with 18 cysteine-rich domains. Unlike chordin, KCP enhances BMP signaling in a paracrine manner. Smad1-dependent transcription and phosphorylated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.