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Article

Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse, a model of autosomal recessive polycystic kidney disease.

American journal of physiology. Renal physiology - 1 Dec 2017

Hama Taketsugu, Nakanishi Koichi, Sato Masashi, Mukaiyama Hironobu, Togawa Hiroko, Shima Yuko, Miyajima Masayasu, Nozu Kandai, Nagao Shizuko, Takahashi Hisahide, Sako Mayumi, Iijima Kazumoto, Yoshikawa Norishige, Suzuki Hiroyuki

Abstract excerpt

Cystic epithelia acquire mesenchymal-like features in polycystic kidney disease (PKD). In this phenotypic alteration, it is well known that transforming growth factor (TGF)-β/Smad3 signaling is involved; however, there is emerging new data on Smad3 phosphoisoforms: Smad3 phosphorylated at linker regions (pSmad3L), COOH-terminal regions (pSmad3C), and both (pSmad3L/C). pSmad3L/C has a pathological role in...

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Source

Identifiers

PMID: 28877884
DOI: 10.1152/ajprenal.00697.2016

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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