Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations.

The American journal of pathology - 1 Nov 2000

Yang S P, Woolf A S, Yuan H T, Scott R J, Risdon R A, O'Hare M J, Winyard P J

Abstract excerpt

Transformations between epithelial and mesenchymal cells are widespread during normal development and adult disease, and transforming growth factor-beta1 (TGF-beta1) has been implicated in some of these phenotypic switches. Dysplastic kidneys are a common cause of chronic kidney failure in young children and result from perturbed epithelial-mesenchymal interactions. In this study, we found that components of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Abnormalities
Share to Fetus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Infant

Share to Kidney

Share to Reference Values

Share to Transforming Growth Factor beta

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 11073823
DOI: 10.1016/s0002-9440(10)64801-8
PMCID: PMC3277215

Genes

BCL2
MET
PAX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations.PMID 11073823Read ↗

Recapitulation of Embryological Programmes in Renal Fibrosis – The Importance of Epithelial Cell Plasticity and Developmental GenesSemantic proximity Read ↗

The differential expression of TGF-β1, ILK and wnt signaling inducing epithelial to mesenchymal transition in human renal fibrogenesis: an immunohistochemical study.Semantic proximity Read ↗

The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations.Semantic proximity Read ↗

Cystic disease of the kidney.Semantic proximity Read ↗

A Critical Look at Growth Factors and Epithelial-to-Mesenchymal Transition in the Adult KidneySemantic proximity Read ↗

Molecular regulation of kidney developmentSemantic proximity Read ↗

Epithelial-mesenchymal transition and its implications for fibrosisSemantic proximity Read ↗

Epithelial-mesenchymal transition and its implications for fibrosisSemantic proximity Read ↗

β-Catenin Causes Renal Dysplasia via Upregulation of Tgfβ2 and Dkk1Semantic proximity Read ↗

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β familySemantic proximity Read ↗

TGF-β controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription in miceSemantic proximity Read ↗

MKL1 mediates TGF‐β‐induced CTGF transcription to promote renal fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.