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Article

Nmp4/CIZ closes the parathyroid hormone anabolic window.

Critical reviews in eukaryotic gene expression - 1 Jan 2012

Bidwell Joseph P, Childress Paul, Alvarez Marta B, Hood Mark, He Yongzheng, Pavalko Fredrick M, Kacena Melissa A, Yang Feng-Chun

Abstract excerpt

Chronic degenerative diseases are increasing with the aging U.S. population. One consequence of this phenomenon is the need for long-term osteoporosis therapies. Parathyroid hormone (PTH), the only FDA-approved treatment that adds bone to the aged skeleton, loses its potency within two years of initial treatment but the mechanism regulating its limited "anabolic window" is unknown. We have discovered that...

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Identifiers

PMID: 23140162
DOI: 10.1615/critreveukargeneexpr.v22.i3.40
PMCID: PMC3586259

Genes

PTH
BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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