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Article

Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling.

Developmental cell - 31 Mar 2014

Mass Elvira, Wachten Dagmar, Aschenbrenner Anna C, Voelzmann André, Hoch Michael

Abstract excerpt

Calcineurin is a heteromeric Ca(2+)-dependent serine/threonine phosphatase. It dephosphorylates the transcription factor nuclear factor of activated T cells (NFAT) in the cytoplasm, which subsequently undergoes nuclear translocation. NFAT regulates numerous biological processes, including inflammatory T cell responses and cardiac development. Our study identifies the Cysteine-Rich with EGF-Like Domains 1 (Creld1)...

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Identifiers

PMID: 24697899
DOI: 10.1016/j.devcel.2014.02.012

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EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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