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Article

Six2creFrs2α knockout mice are a novel model of renal cystogenesis.

Scientific reports - 17 Nov 2016

Puri Pawan, Bushnell Daniel, Schaefer Caitlin M, Bates Carlton M

Abstract excerpt

Six2cre-mediated deletion of Frs2α (Six2creFrs2αKO), a major fibroblast growth factor receptor (Fgfr) docking protein in mouse nephron progenitors results in perinatal renal hypoplasia; however, postnatal Six2creFrs2αKO kidneys develop cysts. We sought to determine the pathogenesis of Six2creFrs2αKO cyst formation. We performed histological assays, Western blots, and quantitative PCR (qPCR). While embryonic day...

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Identifiers

PMID: 27853247
DOI: 10.1038/srep36736
PMCID: PMC5113122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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