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Article

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.

Open biology - 19 Feb 2014

Vogt Janis, Dingwell Kevin S, Herhaus Lina, Gourlay Robert, Macartney Thomas, Campbell David, Smith James C, Sapkota Gopal P

Abstract excerpt

Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8. In the canonical pathway, this triggers the association of these SMADs with SMAD4 and their translocation to the nucleus, where they regulate gene expression. BMPs can also signal independently of SMAD4, but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24554596
DOI: 10.1098/rsob.130210
PMCID: PMC3938053

Genes

SMAD4
SMAD1
ASNS
NEDD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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