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Article

Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice.

The Journal of biological chemistry - 3 Jun 2005

Bubikat Alexander, De Windt León J, Zetsche Bernd, Fabritz Larissa, Sickler Heidrun, Eckardt Dominik, Gödecke Axel, Baba Hideo A, Kuhn Michaela

Abstract excerpt

The crucial functions of atrial natriuretic peptide (ANP) and endothelial nitric oxide/NO in the regulation of arterial blood pressure have been emphasized by the hypertensive phenotype of mice with systemic inactivation of either the guanylyl cyclase-A receptor for ANP (GC-A-/-) or endothelial nitric-oxide synthase (eNOS-/-). Intriguingly, similar levels of arterial hypertension are accompanied by marked cardiac...

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Identifiers

PMID: 15793309
DOI: 10.1074/jbc.M501103200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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