Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice.

doi:10.1161/HYPERTENSIONAHA.109.147207

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Article

Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice.

Hypertension (Dallas, Tex. : 1979) - 1 May 2010

Wakui Hiromichi, Tamura Kouichi, Tanaka Yutaka, Matsuda Miyuki, Bai Yunzhe, Dejima Toru, Masuda Shin-Ichiro, Shigenaga Atsu-Ichiro, Maeda Akinobu, Mogi Masaki, Ichihara Naoaki, Kobayashi Yusuke, Hirawa Nobuhito, Ishigami Tomoaki, Toya Yoshiyuki, Yabana Machiko, Horiuchi Masatsugu, Minamisawa Susumu, Umemura Satoshi

Abstract excerpt

We cloned a novel molecule interacting with angiotensin II type 1 receptor, which we named ATRAP (for angiotensin II type 1 receptor-associated protein). Previous in vitro studies showed that ATRAP significantly promotes constitutive internalization of the angiotensin II type 1 receptor and further attenuates angiotensin II-mediated hypertrophic responses in cardiomyocytes. The present study was designed to...

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PMID: 20231526
DOI: 10.1161/HYPERTENSIONAHA.109.147207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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