Article
Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death.
American journal of physiology. Heart and circulatory physiology - 1 Jun 2009
Yasuno Shinji, Usami Satoru, Kuwahara Koichiro, Nakanishi Michio, Arai Yuji, Kinoshita Hideyuki, Nakagawa Yasuaki, Fujiwara Masataka, Murakami Masao, Ueshima Kenji, Harada Masaki, Nakao Kazuwa
Abstract excerpt
Ventricular myocytes are known to show increased expression of the cardiac hormones atrial and brain natriuretic peptide (ANP and BNP, respectively) in response to pathological stress on the heart, but their function during the progression of nonischemic dilated cardiomyopathy remains unclear. In this study, we crossed a mouse model of dilated cardiomyopathy and sudden death, which we generated by...
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