Article
Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B.
Proceedings of the National Academy of Sciences of the United States of America - 21 Mar 2006
Langenickel Thomas H, Buttgereit Jens, Pagel-Langenickel Ines, Lindner Maren, Monti Jan, Beuerlein Knut, Al-Saadi Nidal, Plehm Ralph, Popova Elena, Tank Jens, Dietz Rainer, Willenbrock Roland, Bader Michael
Abstract excerpt
Natriuretic peptides (NP) mediate their effects by activating membrane-bound guanylyl cyclase-coupled receptors A (NPR-A) or B (NPR-B). Whereas the pathophysiological role of NPR-A has been widely studied, only limited knowledge on the cardiovascular function of NPR-B is available. In vitro studies suggest antiproliferative and antihypertrophic actions of the NPR-B ligand C-type NP (CNP). Because of the lack of a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.