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Article

Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA.

Development (Cambridge, England) - 1 Sept 1993

Kim-Ha J, Webster P J, Smith J L, Macdonald P M

Abstract excerpt

Pattern formation in the early development of many organisms relies on localized cytoplasmic proteins, which can be prelocalized as mRNAs. The Drosophila oskar gene, required both for posterior body patterning and germ cell determination, encodes one such mRNA. Localization of oskar mRNA is an elaborate process involving movement of the transcript first into the oocyte from adjacent interconnected nurse cells and...

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Identifiers

PMID: 8275853
DOI: 10.1242/dev.119.1.169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA.PMID 8275853Read ↗

oskar mRNA is localized to the posterior pole of the Drosophila oocyte.Semantic proximity Read ↗

Oskar organizes the germ plasm and directs localization of the posterior determinant nanos.Semantic proximity Read ↗

BREs mediate both repression and activation of oskar mRNA translation and act in trans.Semantic proximity Read ↗

Multiple cis-acting signals, some weak by necessity, collectively direct robust transport of oskar mRNA to the oocyte.Semantic proximity Read ↗

Two distinct domains of Bruno bind specifically to the oskar mRNA.Semantic proximity Read ↗

Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation.Semantic proximity Read ↗

Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte.Semantic proximity Read ↗

oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.Semantic proximity Read ↗

Systematic Imaging Reveals Features of Localized mRNAs and Their Changing Subcellular Destinations in DevelopmentSemantic proximity Read ↗

Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport.Semantic proximity Read ↗

The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo.Semantic proximity Read ↗

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.Semantic proximity Read ↗

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