Article
oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.
RNA (New York, N.Y.) - 1 Jun 2015
Kanke Matt, Jambor Helena, Reich John, Marches Brittany, Gstir Ronald, Ryu Young Hee, Ephrussi Anne, Macdonald Paul M
Abstract excerpt
The Drosophila oskar (osk) mRNA is unusual in that it has both coding and noncoding functions. As an mRNA, osk encodes a protein required for embryonic patterning and germ cell formation. Independent of that function, the absence of osk mRNA disrupts formation of the karyosome and blocks progression through oogenesis. Here we show that loss of osk mRNA also affects the distribution of regulatory proteins,...
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