Article
Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.
The Journal of biological chemistry - 10 Jun 2005
Oz Gleenberg Iris, Avidan Orna, Goldgur Yehuda, Herschhorn Alon, Hizi Amnon
Abstract excerpt
Recent studies have shown that the integrase (IN) of HIV-1 is inhibited in vitro by HIV-1 reverse transcriptase (RT). We further investigated the specific protein sequences of RT that were involved in this inhibition by screening a complete library of RT-derived peptides for their inhibition of IN activities. Two 20-residue peptides, peptide 4286, derived from the RT DNA polymerase domain, and the one designated...
Topics
- Catalytic Domain
- Dose-Response Relationship, Drug
- Gene Library
- HIV Integrase
- HIV Integrase Inhibitors
- HIV Reverse Transcriptase
- HIV-1
- Inhibitory Concentration 50
- Models, Molecular
- Mutation
- Oligonucleotides
- Peptides
- Protein Binding