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Article

Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.

Bioorganic & medicinal chemistry letters - 24 Mar 2003

Zhao Lei, O'Reilly Mary K, Shultz Michael D, Chmielewski Jean

Abstract excerpt

Peptides derived from the interfacial region of dimeric HIV-1 integrase were evaluated as inhibitors of integrase's 3'-endonuclease activity. Three peptides were found to be moderately potent inhibitors with IC(50) values in the low micromolar range. The mode of inhibition was probed through protein crosslinking experiments. Active interfacial peptides were found to inhibit crosslinking of the dimeric form of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12643937
DOI: 10.1016/s0960-894x(03)00040-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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