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Article

Interaction between HIV-1 Rev and Integrase Proteins

3 Apr 2007

Abstract excerpt

Human immunodeficiency virus 1 (HIV-1) Rev and integrase (IN) proteins are required within the nuclei of infected cells in the late and early phases of the viral replication cycle, respectively. Here we show using various biochemical methods, that these two proteins interact with each other in vitro and in vivo. Peptide mapping and fluorescence anisotropy showed that IN binds residues 1-30 and 49-74 of Rev....

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PMID: 17403681
DOI: 10.1074/jbc.m609864200

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