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Article

Integrase inhibitors to treat HIV/AIDS.

Nature reviews. Drug discovery - 1 Mar 2005

Pommier Yves, Johnson Allison A, Marchand Christophe

Abstract excerpt

HIV integrase is a rational target for treating HIV infection and preventing AIDS. It took approximately 12 years to develop clinically usable inhibitors of integrase, and Phase I clinical trials of integrase inhibitors have just begun. This review focuses on the molecular basis and rationale for developing integrase inhibitors. The main classes of lead compounds are also described, as well as the concept of...

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PMID: 15729361
DOI: 10.1038/nrd1660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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