Article
Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.
Journal of medicinal chemistry - 27 Jul 2006
Li Hui-Yuan, Zawahir Zahrah, Song Lai-Dong, Long Ya-Qiu, Neamati Nouri
Abstract excerpt
Integration of viral DNA into the host chromosome is an essential step in the HIV life cycle. This process is mediated by integrase (IN), a 32 kDa viral enzyme that has no mammalian counterpart, rendering it an attractive target for antiviral drug design. Herein, we present a novel approach toward elucidating "hot spots" of protein-protein or protein-nucleic acid interactions of IN through the design of peptides...
Topics
- Amino Acid Sequence
- Catalysis
- Circular Dichroism
- Conserved Sequence
- DNA, Viral
- HIV Integrase
- HIV Integrase Inhibitors
- Molecular Sequence Data
- Mutation
- Peptides
- Protein Conformation