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Article

Ile178 of HIV-1 reverse transcriptase is critical for inhibiting the viral integrase.

Biochemical and biophysical research communications - 7 Dec 2007

Oz Gleenberg Iris, Goldgur Yehuda, Hizi Amnon

Abstract excerpt

HIV-1 reverse transcriptase (RT) was shown to inhibit in vitro the viral integrase (IN). We have reported previously that an RT-derived 20-residue peptide binds IN and inhibits its enzymatic activities. In this peptide, Leu168, Phe171, Gln174, and Ile178 were predicted to be involved in IN inhibition. In the presented study, these residues were mutagenized and the resulting peptides were tested for binding and...

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Identifiers

PMID: 17927951
DOI: 10.1016/j.bbrc.2007.09.086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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