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Recent Advances in the Discovery of Small-Molecule Inhibitors of HIV-1 Integrase

6 Sept 2018

Abstract excerpt

AIDS caused by the infection of HIV is a prevalent problem today. Rapid development of drug resistance to existing drug classes has called for the discovery of new targets. Within the three major enzymes (i.e., HIV-1 protease, HIV-1 reverse transcriptase and HIV-1 integrase [IN]) of the viral replication cycle, HIV-1 IN has been of particular interest due to the absence of human cellular homolog. HIV-1 IN...

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PMID: 30416746
DOI: 10.4155/fsoa-2018-0060

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