Article
A novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase.
Journal of molecular biology - 19 Apr 2002
de Soultrait Vaea Richard, Caumont Anne, Parissi Vincent, Morellet Nelly, Ventura Michel, Lenoir Christine, Litvak Simon, Fournier Michel, Roques Bernard
Abstract excerpt
The retroviral encoded protein integrase (IN) is required for the insertion of the human immunodeficiency virus type 1 (HIV-1) proviral DNA into the host genome. In spite of the crucial role played by IN in the retroviral life cycle, which makes this enzyme an attractive target for the development of new anti-AIDS agents, very few inhibitors have been described and none seems to have a potential use in anti-HIV...
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