Article
Expression of steroid hormone receptors in BRCA1-associated ovarian carcinomas.
Gynecologic oncology - 1 Apr 2005
Aghmesheh Morteza, Edwards Lyndal, Clarke Christine L, Byth Karen, Katzenellenbogen Benita S, Russell Pamela J, Friedlander Michael, Tucker Katherine M, de Fazio Anna
Abstract excerpt
OBJECTIVE: BRCA1 mutations predispose to cancer in hormone responsive tissues. A predominance of estrogen receptor (ER)-negative breast cancers in BRCA1 mutation carriers and potential interactions between ERalpha and BRCA1 suggest a link between hormones and BRCA1. However, the expression pattern of ERalpha and other hormone receptors in BRCA1-associated ovarian cancer was unknown. METHODS: Twenty-two...
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