Preferential allelic expression can lead to reduced expression of BRCA1 in sporadic breast cancers.

doi:10.1002/(sici)1097-0215(19980703)77:1<1::aid-ijc1>3.0.co;2-y

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Article

Preferential allelic expression can lead to reduced expression of BRCA1 in sporadic breast cancers.

International journal of cancer - 3 Jul 1998

Ozçelik H, To M D, Couture J, Bull S B, Andrulis I L

Abstract excerpt

BRCA1 is considered to be a tumor-suppressor gene, yet mutations in this gene are uncommon in sporadic breast tumors. We investigated whether mechanisms other than DNA mutations that affect the coding region might be involved in breast carcinogenesis. Since loss of expression of the BRCA1 gene wo...

Topics

Alleles
BRCA1 Protein
Breast Neoplasms
Female
Gene Expression Regulation, Neoplastic
Humans
Mutation

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