Proliferation and ovarian hormone signaling are impaired in normal breast tissues from women with BRCA1 mutations: benefit of a progesterone receptor modulator treatment as a breast cancer preventive strategy in women with inherited BRCA1 mutations.

doi:10.18632/oncotarget.9638

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Proliferation and ovarian hormone signaling are impaired in normal breast tissues from women with BRCA1 mutations: benefit of a progesterone receptor modulator treatment as a breast cancer preventive strategy in women with inherited BRCA1 mutations.

Oncotarget - 19 Jul 2016

Communal Laudine, Vilasco Myriam, Hugon-Rodin Justine, Courtin Aurélie, Mourra Najat, Lahlou Najiba, Le Guillou Morwenna, Perrault de Jotemps Muriel, Chauvet Marie-Pierre, Chaouat Marc, Pujol Pascal, Feunteun Jean, Delaloge Suzette, Forgez Patricia, Gompel Anne

Abstract excerpt

Women with inherited BRCA1 mutations have an elevated risk (40-80%) for developing breast and ovarian cancers. Reproductive history has been reported to alter this risk, suggesting a relationship between ovarian hormone signaling and BRCA1-related tumor development. BRCA1 interactions with estrogen receptor (ER) and progesterone receptor (PR) signaling were previously described in human breast cancer cell lines...

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Identifiers

PMID: 27246982
DOI: 10.18632/oncotarget.9638
PMCID: PMC5216725

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BRCA1
FASN

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Source receipt: pubmed, retrieved 7 Sept 2026.

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