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Article

Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer.

Cancer research - 15 Jul 2002

Chan Kelvin Y K, Ozçelik Hilmi, Cheung Annie N Y, Ngan Hextan Y S, Khoo Ui-Soon

Abstract excerpt

Hypermethylation of the BRCA1 promoter has previously been shown to cause reduced mRNA expression in both breast and ovarian cancers. Nothing is yet known of the expression pattern or methylation status of the promoter region of BRCA2 in sporadic ovarian cancer. Whereas our analysis of 30 sporadic ovarian carcinomas showed a statistically significant reduction of BRCA1 mRNA expression (P = 0.001), it also showed,...

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Share to DNA Methylation
Share to Gene Amplification
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to Ovarian Neoplasms

Share to Promoter Regions, Genetic

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 12124354

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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