Article
Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis.
Blood - 1 Jul 2005
Baldwin Clinton, Nolan Vikki G, Wyszynski Diego F, Ma Qian-Li, Sebastiani Paola, Embury Stephen H, Bisbee Alice, Farrell John, Farrer Lindsay, Steinberg Martin H
Abstract excerpt
In patients with sickle cell disease, clinical complications including osteonecrosis can vary in frequency and severity, presumably due to the effects of genes that modify the pathophysiology initiated by the sickle mutation. Here, we examined the association of single nucleotide polymorphisms (SNPs) in candidate genes (cytokines, inflammation, oxidant stress, bone metabolism) with osteonecrosis in patients with...
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