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Genomic polymorphisms in sickle cell disease: implications for clinical diversity and treatment.

Expert review of hematology - 1 Aug 2010

Fertrin Kleber Yotsumoto, Costa Fernando Ferreira

Abstract excerpt

Sickle cell disease (SCD) is one of the best characterized human monogenic disorders. The development of molecular biology allowed the identification of several genomic polymorphisms responsible for its clinical diversity. Research on the first genetic modulators of SCD, such as coinheritance of α-thalassemia and haplotypes in the β-globin gene cluster, have been followed by studies associating single nucleotide...

Topics

Anemia, Sickle Cell
Antisickling Agents
Blood Transfusion
Fetal Hemoglobin
Genome-Wide Association Study
Humans
Hydroxyurea
Male
Polymorphism, Genetic
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21083035
DOI: 10.1586/ehm.10.44

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SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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