Polymorphisms in Inflammatory Genes Modulate Clinical Complications in Patients With Sickle Cell Disease.

doi:10.3389/fimmu.2020.02041

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Article

Polymorphisms in Inflammatory Genes Modulate Clinical Complications in Patients With Sickle Cell Disease.

Frontiers in immunology - 1 Jan 2020

Tozatto-Maio Karina, Girot Robert, Ly Indou Deme, Silva Pinto Ana Cristina, Rocha Vanderson, Fernandes Francisco, Diagne Ibrahima, Benzerara Yahia, Dinardo Carla L, Soler Julia Pavan, Kashima Simone, Araujo Itauá Leston, Kenzey Chantal, Fonseca Guilherme H H, Rodrigues Evandra S, Volt Fernanda, Jarduli Luciana, Ruggeri Annalisa, Mariaselvam Christina, Gualandro Sandra F M, Rafii Hanadi, Cappelli Barbara, Nogueira Felipe Melo, Scigliuolo Graziana Maria, Guerino-Cunha Renato Luiz, Malmegrim Kelen Cristina Ribeiro, Simões Belinda P, Gluckman Eliane, Tamouza Ryad

Abstract excerpt

Sickle cell disease (SCD), the most common monogenic disease worldwide, is marked by a phenotypic variability that is, to date, only partially understood. Because inflammation plays a major role in SCD pathophysiology, we hypothesized that single nucleotide polymorphisms (SNP) in genes encoding functionally important inflammatory proteins might modulate the occurrence of SCD complications. We assessed the...

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PMID: 33013863
DOI: 10.3389/fimmu.2020.02041
PMCID: PMC7510050

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