Article
Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease.
Blood - 15 Jun 2008
Ashley-Koch Allison E, Elliott Laine, Kail Melanie E, De Castro Laura M, Jonassaint Jude, Jackson Terry L, Price Jennifer, Ataga Kenneth I, Levesque Marc C, Weinberg J Brice, Orringer Eugene P, Collins Ann, Vance Jeffery M, Telen Marilyn J
Abstract excerpt
Up to 30% of adult patients with sickle cell disease (SCD) will develop pulmonary hypertension (pHTN), a complication associated with significant morbidity and mortality. To identify genetic factors that contribute to risk for pHTN in SCD, we performed association analysis with 297 single nucleotide polymorphisms (SNPs) in 49 candidate genes in patients with sickle cell anemia (Hb SS) who had been screened for...
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