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Article

Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway.

British journal of haematology - 1 Jun 2006

Nolan Vikki G, Adewoye Adeboye, Baldwin Clinton, Wang Ling, Ma Qianli, Wyszynski Diego F, Farrell John J, Sebastiani Paola, Farrer Lindsay A, Steinberg Martin H

Abstract excerpt

Cutaneous leg ulcers are common in sickle cell anaemia and their risk might be genetically determined. Sickle cell anaemia patients were studied to examine the relationship of leg ulcers with haemolysis and with single nucleotide polymorphisms (SNPs) in candidate genes that could affect sickle vasoocclusion. Leg ulcer patients had lower haemoglobin levels and higher levels of lactate dehydrogenase, bilirubin,...

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Share to Anemia, Sickle Cell
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronidase

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Share to Klotho Proteins

Share to Receptor, TIE-2

Share to Thalassemia

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 16681647
DOI: 10.1111/j.1365-2141.2006.06074.x
PMCID: PMC1679888

Genes

TEK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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