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Article

BMP6 and VDR gene polymorphisms are associated with osteonecrosis in a sickle cell anaemia cohort.

British journal of haematology - 1 Apr 2024

Arcanjo Gabriela S, Souza Mariana B, Domingos Igor F, Pereira-Martins Diego A, Falcão Diego A, Batista Jessica V, Hatzlhofer Betania L, Diniz Madi V, Silva Alexsandro P, Guaraná Werbson L, Hazin Manuela F, Araujo Aderson S, Cunha Anderson F, Saad Sara O, Costa Fernando F, Lucena-Araujo Antonio R, Bezerra Marcos André C

Abstract excerpt

The occurrence and severity of osteonecrosis in sickle cell anaemia (SCA) vary due to risk factors, including genetic modifiers. Bone morphogenetic proteins (BMPs), particularly BMP6, and the vitamin D receptor (VDR) play key roles in cartilage and bone metabolism, making them potential contributors to orthopaedic outcomes in SCA. Here, we evaluated the association of polymorphisms in BMP6 (rs3812163, rs270393...

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Share to Anemia, Sickle Cell
Share to Case-Control Studies
Share to Genetic Predisposition to Disease
Share to Genotype
Share to Osteonecrosis
Share to Polymorphism, Single Nucleotide
Share to Receptors, Calcitriol
Share to Risk Factors

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Identifiers

PMID: 38323352
DOI: 10.1111/bjh.19329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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