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Article

Association between rs267196 and rs267201 of BMP6 gene and osteonecrosis among sickle cell aneamia patients.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia - 1 Mar 2015

Chaouch Leila, Kalai Miniar, Jbara Manel Ben, Chaabene Arij Ben, Darragi Imen, Chaouachi Dorra, Mallouli Fethi, Hafsia Raouf, Ghanem Abderraouf, Abbes Salem

Abstract excerpt

AIMS: The skeletal manifestations of sickle cell disease are the result of changes in bone and bone marrow caused by chronic tissue hypoxia that is exacerbated by episodic occlusion of the microcirculation by the abnormal sickle cells. Furthermore, the occurrence of osteonecrosis is under the control of some modifier gene. BMP6 (Bone morphogenetic protein) has been reported as associated with osteonecrosis in...

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Share to Anemia, Sickle Cell
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Osteonecrosis

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Risk Factors

Share to RNA, Neoplasm

Source

Identifiers

PMID: 24263212
DOI: 10.5507/bp.2013.080

Genes

BMP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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