Article
Association of KLOTHO polymorphisms with clinical complications of sickle cell anemia.
Annals of hematology - 1 Aug 2021
Batista Jéssica V G F, Pereira-Martins Diego A, Falcão Diego A, Domingos Igor F, Arcanjo Gabriela S, Hatzlhofer Betânia L, Weinhäuser Isabel, Batista Thais H C, Cardoso Pablo R G, Dos Anjos Ana C, Hazin Manuela F, Pitta Maira G R, Costa Fernando F, Araujo Aderson S, Lucena-Araujo Antonio R, Bezerra Marcos A
Abstract excerpt
The clinical and phenotypic heterogeneity of patients with sickle cell anemia (SCA) is influenced by environmental and genetic factors. Several genetic modifiers, such as the KLOTHO (KL) gene, have been associated with SCA clinical outcomes. The KL gene and its encoded proteins are implicated in important biological pathways, which affect the disease's pathophysiology, such as expression of adhesion molecules...
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