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Article

Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.

British journal of haematology - 1 Sept 2015

Mizutani Shinsuke, Yoshida Tatsushi, Zhao Xinyang, Nimer Stephen D, Taniwaki Masafumi, Okuda Tsukasa

Abstract excerpt

RUNX1 (previously termed AML1) is a frequent target of human leukaemia-associated gene aberrations, and it encodes the DNA-binding subunit of the Core-Binding Factor transcription factor complex. RUNX1 expression is essential for the initiation of definitive haematopoiesis, for steady-state thrombopoiesis, and for normal lymphocytes development. Recent studies revealed that protein arginine methyltransferase 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26010396
DOI: 10.1111/bjh.13499
PMCID: PMC4996932

Genes

RUNX1
PRMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.PMID 26010396Read ↗

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Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.Semantic proximity Read ↗

A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation.Semantic proximity Read ↗

RUNX1 C-terminal mutations impair blood cell differentiation by perturbing specific enhancer-promoter networks.Semantic proximity Read ↗

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitorsSemantic proximity Read ↗

Runx transcription factors in the development and function of the definitive hematopoietic system.Semantic proximity Read ↗

VWRPY motif–dependent and –independent roles of AML1/Runx1 transcription factor in murine hematopoietic developmentSemantic proximity Read ↗

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