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Article

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

21 Mar 2005

Abstract excerpt

This study focused on the screening of small-molecule inhibitors that target signal transducers and activators of transcription 3 (Stat3) in human breast carcinoma. The constitutive activation of Stat3 is frequently detected in human breast cancer cell lines as well as clinical breast cancer specimens and may play an important role in the oncogenesis of breast carcinoma. Activated Stat3 may participate in...

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PMID: 15781862
DOI: 10.1073/pnas.0409894102

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Source receipt: pubmed, retrieved 7 Sept 2026.

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