Article

Synthesis and Evaluation of Naphthalene Derivatives as Potent STAT3 inhibitors and Agents Against Triple-Negative Breast Cancer Growth and Metastasis

2022-09-27

Abstract excerpt

<title>Abstract</title> <p>Purpose Triple-negative breast cancer (TNBC) represents the worst prognostic subtype of breast cancer and lacks targeted therapeutic drugs. Signal transducer and activator of transcription 3 (STAT3) is overexpressed and constitutively activated in TNBCs and associated with poor patient outcomes. However, no agents targeting STAT3 have been successfully developed and marketed. Selective...

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Literature Corpus work: 25783c2b-3111-5dc3-98f7-cc3bbef7a250
DOI: 10.21203/rs.3.rs-1238979/v2

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