Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibiting aberrant Stat3 function with molecular therapeutics

15 Nov 2010

Abstract excerpt

Aberrantly activated signal transducer and activator of transcription 3 (Stat3) protein plays a master regulatory role in the progression and survival of human cancers through the upregulation of target protooncogenes. Numerous human cancers, including breast, ovarian, prostate, leukemia, lymphoma, multiple myeloma, and brain cancers have been shown to harbor constitutively active Stat3 protein resulting in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to PI3K/AKT/mTOR signaling in cancer
Share to Synthesis and biological activity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21063201
DOI: 10.1097/cad.0b013e328341185b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibiting aberrant Stat3 function with molecular therapeuticsPMID 21063201Read ↗

Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) proteinSemantic proximity Read ↗

Strategies and Approaches of Targeting STAT3 for Cancer TreatmentSemantic proximity Read ↗

Novel activators and small-molecule inhibitors of STAT3 in cancerSemantic proximity Read ↗

Critical analysis of the potential for targeting STAT3 in human malignancySemantic proximity Read ↗

STAT3 SIGNALING: Anticancer Strategies and ChallengesSemantic proximity Read ↗

STAT-3 Inhibitors: State of the Art and New Horizons for Cancer TreatmentSemantic proximity Read ↗

Small Molecule Inhibitors of STAT3 for Cancer TherapySemantic proximity Read ↗

Oncogenic STAT Transcription Factors as Targets for Cancer Therapy: Innovative Strategies and Clinical TranslationSemantic proximity Read ↗

STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancersSemantic proximity Read ↗

Overview of the STAT‑3 signaling pathway in cancer and the development of specific inhibitors (Review)Semantic proximity Read ↗

Signal transducer and activator of transcription 3 inhibitors: a patent reviewSemantic proximity Read ↗

Targeting the Cytoplasmic and Nuclear Functions of Signal Transducers and Activators of Transcription 3 for Cancer TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.