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Article

Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s.

Cancer research - 15 Mar 2005

Kakudo Yuichi, Shibata Hiroyuki, Otsuka Kazunori, Kato Shunsuke, Ishioka Chikashi

Abstract excerpt

Tumor suppressor p53-dependent apoptosis is thought to be one of the most important tumor-suppressive functions in human tumorigenesis. However, whether the major mechanism underlying the p53-dependent apoptosis is transactivation dependent or independent remains unclear. Using 179 mutant p53s with diverse transcriptional activities for distinct p53-binding sequences in yeast, we evaluated both their...

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Identifiers

PMID: 15781620
DOI: 10.1158/0008-5472.CAN-04-2935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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