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Article

A single mutant, A276S of p53, turns the switch to apoptosis.

Molecular pharmaceutics - 1 Apr 2013

Reaz Shams, Mossalam Mohanad, Okal Abood, Lim Carol S

Abstract excerpt

The tumor suppressor protein p53 induces apoptosis, cell cycle arrest, and DNA repair along with other functions in a transcription-dependent manner [Vousden, K. H. Cell 2000, 103(5), 691-694]. The selection of these functions depends on sequence-specific recognition of p53 to a target decameric sequence of gene promoters [Kitayner, M.; et al. Mol. Cell 2006, 22(6), 741-753]. Amino acid residues in p53 that...

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Identifiers

PMID: 23402381
DOI: 10.1021/mp300598k
PMCID: PMC3658472

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PERP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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