Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo.

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Article

Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo.

Oncogene - 20 Apr 1995

Ishioka C, Englert C, Winge P, Yan Y X, Engelstein M, Friend S H

Abstract excerpt

Increasing evidence indicates that p53 is a transcriptional trans-activator through its sequence-specific DNA binding domain. Tumor-derived p53 mutations disrupt the trans-activation ability mainly due to loss of its sequence-specific DNA binding. Using both yeast and mammalian cell assays, the e...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Cycle
Cell Division
DNA, Complementary
Molecular Sequence Data
Mutation
Structure-Activity Relationship
Transcriptional Activation
Tumor Suppressor Protein p53
Yeasts

Source

Open in PubMed

Identifiers

PMID: 7731702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7731702-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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