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Article

Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain.

Cancer science - 1 Feb 2020

Suzuki Shiori, Tsutsumi Shuichi, Chen Yu, Ozeki Chikako, Okabe Atsushi, Kawase Tatsuya, Aburatani Hiroyuki, Ohki Rieko

Abstract excerpt

The tumor suppressor gene p53 encodes a transcriptional activator that has two transactivation domains (TAD) located in its amino terminus. These two TAD can transactivate genes independently, and at least one TAD is required for p53 transactivation function. The 1st TAD (a.a. 1-40) is essential for the induction of numerous classical p53 target genes, while the second TAD (a.a. 41-61) suffices for tumor...

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Identifiers

PMID: 31834974
DOI: 10.1111/cas.14279
PMCID: PMC7004532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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